Emergence of Helical Assemblies in Binary Solvents <italic style="font-style: italic">via</italic> Grafting-from Polymerization-induced Self-assembly of Nanoparticles

Yuqi Guo; Minhui Gao; Lijun Ma; Fenzhao Liu; Hong Liu; Yingxiang Li

doi:10.1007/s10118-026-3883-3

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Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles

RESEARCH ARTICLE | 更新时间：2026-10-30

- Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles
- Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles
- Chinese Journal of Polymer Science 2026年44卷页码：1-11
- 作者机构：
  
  a.Department of Chemical and Material Engineering, Lyuliang University, Lvliang 033001, China
  b.Key Laboratory of Theoretical Chemistry of Environment Ministry of Education, School of Environment, South China Normal University, Guangzhou 510006, China
  c.School of Chemistry, South China Normal University, Guangzhou 510006, China
- 作者简介：
  
  hongliu@m.scnu.edu.cn (H.L.)
  yingxiangli@m.scnu.edu.cn (Y.L.)
- 基金信息：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 22403059, 22503036, 22573037, 22273027 and 22373024), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (STIP) (No. 2025Q039), and The Science and Technology Plan Project of Lvliang (No. 2023GXYF08). H.L. gratefully acknowledges support from the Alexander von Humboldt Foundation.;The authors declare no interest conflict.The data supporting the findings of this study are available from the corresponding author upon reasonable request. Contact information: Yingxiangli@m.scnu.edu.cn.
- DOI：10.1007/s10118-026-3883-3
  中图分类号：
- 收稿：2026-08-02，
  
  录用：2026-09-09，
  
  网络首发：2026-10-30，
  
  纸质出版：2026-10
- 稿件说明：
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Guo, Y.; Gao, M.; Ma, L.; Liu, F.; Liu, H.; Li, Y. Emergence of helical assemblies in binary solvents via grafting-from polymerization-induced self-assembly of nanoparticles. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3883-3

Yuqi Guo, Minhui Gao, Lijun Ma, et al. Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles[J/OL]. Chinese Journal of Polymer Science, 2026, 441-11. DOI: 10.1007/s10118-026-3883-3.
Guo, Y.; Gao, M.; Ma, L.; Liu, F.; Liu, H.; Li, Y. Emergence of helical assemblies in binary solvents via grafting-from polymerization-induced self-assembly of nanoparticles. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3883-3 DOI：

Yuqi Guo, Minhui Gao, Lijun Ma, et al. Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles[J/OL]. Chinese Journal of Polymer Science, 2026, 441-11. DOI: 10.1007/s10118-026-3883-3. DOI：

摘要

Abstract

Compared with micelles and vesicles formed by the aggregation of conventional polymer chains

the aggregates of grafted nanoparticles demonstrate superior performance in structural stability

functional diversity

and application adaptability. These characteristics indicate their greater potential in fields such as drug delivery

biomateri

als

and intelligent responsive systems. To further expand the range of achievable morphologies

this study introduces co-solvent effects into polymer-grafted nanoparticle systems assembled

via

polymerization-induced self-assembly (PISA). A nanoparticle model featuring dual symmetric initiation sites was developed

and dissipative particle dynamics (DPD) simulations were combined with a stochastic polymerization reaction to systematically investigate the influence of co-solvent interaction strength

nanoparticle filling ratio

and hydrophobic chain length on the self-assembly behavior of grafted nanoparticles. The results reveal that

by precisely tuning the simulation parameters

the controlled formation of various morphologies can be achieved

ranging from conventional spherical and lamellar structures to highly ordered helical aggregates which are preferentially formed when both solvents are strongly solvophobic toward the grafted chains

while a slight asymmetry exists between the two solvent–chain interaction strengths. These findings offer new theoretical insights and methodological support for the morphological control and functional design of polymer-based nanocomposites.

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references

Penfold, N. J. W.; Yeow, J.; Boyer, C.; Armes, S. P. Emerging trends in polymerization-induced self-assembly. ACS Macro Lett. 2019 , 8 , 1029−1054..

Paul, D. R.; Robeson, L. M. Polymer nanotechnology: nanocomposites. Polymer 2008 , 49 , 3187−3204..

Kirakosyan, A.; Kim, D.; Choi, J. Self-assembled polymer-grafted nanoparticles for photonic coating applications. Macromol. Res. 2016 , 24 , 1030−1035..

Le Goas, M.; Paquirissamy, A.; Gargouri, D.; F adda, G.; Testard, F.; Aymes-Chodur, C.; Jubeli, E.; Pourcher, T.; Cambien, B.; Palacin, S.; Renault, J.; Carrot, G. Irradiation effects on polymer-grafted gold nanoparticles for cancer therapy. ACS Appl. Bio Mater. 2019 , 2 , 144−154..

Masucci, A. E.; Ghasemi, M.; Pester, C. W.; Gomez, E. D. Enhancing photoluminescence of conjugated nanoparticles through graft polymer architectures. Mater. Adv. 2023 , 4 , 2586−2594..

Xie, C.; Zhou, W.; Zeng, Z.; Fan, Q.; Pu, K. Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy. Chem. Sci. 2020 , 11 , 10553−10570..

Maity, N.; Ghosh, R.; Nandi, A. K. Optoelectronic properties of self-assembled nanostructures of polymer functionalized polythiophene and graphene. Langmuir 2018 , 34 , 7585−7597..

Song, W. Y.; Lu, H.; He, J. W.; Zhu, Z. J.; He, S. Y.; Liu, D. H.; Liu, H.; Wang, Y. Dynamics and morphology of self-assembly behavior of polymer-grafted nanoparticles: a dissipative particle dynamics simulation study. Polym. Int. 2022 , 71 , 1330−1339..

Moinuddin, M.; Tripathy, M. Effect of architecture and topology on the self-assembly of polymer-grafted nanoparticles. Macromolecules 2022 , 55 , 9312−9323..

Chen, P.; Yang, Y.; Dong, B.; Huang, Z.; Zhu, G.; Cao, Y.; Yan, L.-T. Polymerization-induced interfacial self-assembly of Janus nanoparticles in block copolymers: reaction-mediated entropy effects, diffusion dynamics, and tailorable micromechanical behaviors. Macromolecules 2017 , 50 , 2078−2091..

Cabral, H.; Matsumoto, Y.; Mizuno, K.; Chen, Q.; Murakami, M.; Kimura, M.; Terada, Y.; Kano, M. R.; Miyazono, K.; Uesaka, M.; Nishiyama, N.; Kataoka, K. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 2011 , 6 , 815−823..

Liu, D.; Cai, W.; Zhang, L.; Boyer, C.; Tan, J. Efficient photoinitiated polymerization-induced self-assembly with oxygen tolerance through dual-wavelength type I photoinitiation and photoinduced deoxygenation. Macromolecules 2020 , 53 , 1212−1223..

Sun, P.; Yang, C.; Peng, F.; Dang, J.; Wang, W.; Deng, D.; Zhang, N. N.; Yang, Y.; Liu, K. Free-radical polymerization induced grafting-to of polymer chains onto aluminum n anoparticles. Chin. J. Chem. 2024 , 42 , 3193−3200..

Li, S.; Liu, X.; Zhang, H.; Mao, Y.; Zhang, T.; Wang, J. Shape-tunable polymeric Janus nanoparticles with hollow cavities derived from polymerization induced self-assembly based crosslinked vesicles. Chem. Commun. 2022 , 58 , 2228−2231..

Xu, X. F.; Zhu, R. M.; Pan, C. Y.; You, Y. Z.; Zhang, W. J.; Hong, C. Y. Polymerization-induced self-assembly driven by the synergistic effects of aromatic and solvophobic interactions. Macromolecules 2021 , 54 , 2729−2739..

Charleux, B.; Delaittre, G.; Rieger, J.; D’Agosto, F. Polymerization-induced self-assembly: from soluble macromolecules to block copolymer nano-objects in one step. Macromolecules 2012 , 45 , 6753−6765..

Campos-Villalobos, G.; Siperstein, F. R.; Charles, A.; Patti, A. Solvent-induced morphological transitions in methacrylate-based block-copolymer aggregates. J. Colloid Interface Sci. 2020 , 572 , 133−140..

Gyorgy, C.; Armes, S. P. Recent advances in polymerization-induced self-assembly (PISA) syntheses in non-polar media. Angew. Chem. Int. Ed. 2023 , 62 , e202308372..

Huang, Y.; Cheng, S. Chain conformations and phase separation in polymer solutions with varying solvent quality. J. Polym. Sci. 2021 , 59 , 2819−2831..

Mukherji, D.; Marques, C. M.; Kremer, K. Polymer collapse in miscible good solvents is a generic phenomenon driven by preferential adsorption. Nat. Commun. 2014 , 5 , 4882..

Zhang, G.; Wu, C. Reentrant coil-to-globule-to-coil transition of a single linear homopolymer chain in a water/methanol mixture. Phys. Rev. Lett. 2001 , 86 , 822−825..

Mukherji, D.; Marques, C. M.; Stuehn, T.; Kremer, K. Depleted depletion drives polymer swelling in poor solvent mixtures. Nat. Commun. 2017 , 8 , 1374..

Dudowicz, J.; Freed, K. F.; Douglas, J. F. Communication: cosolvency and cononsolvency explained in terms of a Flory-Huggins type theory. J. Chem. Phys. 2015 , 143 , 131101..

Bharadwaj, S.; Niebuur, B. J.; Nothdurft, K.; Richtering, W.; van der Vegt, N. F. A.; Papadakis, C. M. Cononsolvency of thermoresponsive polymers: where we are now and where we are going. Soft Matter 2022 , 18 , 2884−2909..

Wan, J.; Fan, B.; Thang, S. H. RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions. Chem. Sci. 2022 , 13 , 4192−4224..

Serkhacheva, N. S.; Prokopov, N. I.; Lysenko, E. A.; Kozhunova, E. Y.; Chernikova, E. V. Modern trends in polymerization-induced self-assembly. Polymers 2024 , 16 , 1408..

Liu, H.; Zhu, Y. L.; Lu, Z. Y.; Muller-Plathe, F. A kinetic chain growth algorithm in coarse-grained simulations. J. Comput. Chem. 2016 , 37 , 2634−2646..

Yi, C.; Yang, Y.; Liu, B.; He, J.; Nie, Z. Polymer-guided assembly of inorganic nanoparticles. Chem. Soc. Rev. 2020 , 49 , 465−508..

Chao, H.; Riggleman, R. A. Effect of particle size and grafting density on the mechanical properties of polymer nanocomposites. Polymer 2013 , 54 , 5222−5229..

Akcora, P.; Kumar, S. K.; García Sakai, V.; Li, Y.; Benicewicz, B. C.; Schadler, L. S. Segmental dynamics in PMMA-grafted nanoparticle composites. Macromolecules 2010 , 43 , 8275−8281..

Deng, L.-Y. Orthogonal arrays: theory and applications. Technometrics 2000 , 42 , 440..

Li, L.; Han, C.; Xu, D.; Xing, J. Y.; Xue, Y. H.; Liu, H. Polymer-grafted nanoparticles prepared via a grafting-from strategy: a computer simulation study. Phys. Chem. Chem. Phys. 2018 , 20 , 18400−18409..

Xing, J. Y.; Lu, Z. Y.; Liu, H.; Xue, Y. H. The selectivity of nanoparticles for polydispersed ligand chains during the grafting-to process: a computer simulation study. Phys. Chem. Chem. Phys. 2018 , 20 , 2066−2074..

Yan, Y. D.; Xue, Y. H.; Zhao, H. Y.; Liu, H.; Lu, Z. Y.; Gu, F. L. Insight into the polymerization-induced sel f-assembly via a realistic computer simulation strategy. Macromolecules 2019 , 52 , 6169−6180..

Li, C. X.; Mao, J. Y.; Li, S. J.; Wang, Y.; Liu, H. A long chain-induced depletion effect for abnormal grafting in the preparation of bimodal bidisperse polymer-grafted nanoparticles. Phys. Chem. Chem. Phys. 2023 , 25 , 5627−5637..

Chai, Q. P.; Guo, Y. Q.; Gao, M. H.; Wang, Y.; Liu, H. Polymerization-induced self-assembly of patchy nanoparticles: a simulation study. Acta Polymerica Sinica (in Chinese) 2025 , 56 , 1234−1246..

Kim, A.; Kim, C.; Waltmann, T.; Vo, T.; Kim, E. M.; Kim, J.; Shao, Y. T.; Michelson, A.; Crockett, J. R.; Kalutantirige, F. C.; Yang, E.; Yao, L.; Hwang, C. Y.; Zhang, Y.; Liu, Y. S.; An, H.; Gao, Z.; Kim, J.; Mandal, S.; Muller, D. A.; Fichthorn, K. A.; Glotzer, S. C.; Chen, Q. Patchy nanoparticles by atomic stencilling. Nature 2025 , 646 , 592−600..

Choueiri, R. M.; Galati, E.; Thérien-Aubin, H.; Klinkova, A.; Larin, E. M.; Querejeta-Fernández, A.; Han, L.; Xin, H. L.; Gang, O.; Zhulina, E. B.; Rubinstein, M.; Kumacheva, E. Surface patterning of nanoparticles with polymer patches. Nature 2016 , 538 , 79−83..

Zhang, Z.; Glotzer, S. C. Self-assembly of patchy particles. Nano Lett. 2004 , 4 , 1407−1413..

Zhu, Y.; Liu, H.; Li, Z.; Qian, H.; Milano, G.; Lu, Z. GALAMOST: GPU-accelerated large-scale molecular simulation toolkit. J. Comput. Chem. 2013 , 34 , 2197−2211..

Stukowski, A. Visualization and analysis of atomistic simulation data with OVITO–the open visualization tool. Modelling Simul. Mater. Sci. Eng. 2010 , 18 , 015012..

Martinez, A. P.; Carrillo, J.-M. Y.; Dobrynin, A. V.; Adamson, D. H. Distribution of chains inpolymer brushes produced by a “grafting from” mechanism. Macromolecules 2016 , 49 , 547−553..

Xue, Y. H.; Quan, W.; Liu, X.-L.; Han, C.; Li, H.; Liu, H. Dependence of grafted polymer property on the initiator site distribution in surface-initiated polymerization: a computer simulation study. Macromolecules 2017 , 50 , 6482−6488..

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Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles

Emergence of Helical Assemblies in Binary Solvents via Grafting-from Polymerization-induced Self-assembly of Nanoparticles

DOI：10.1007/s10118-026-3883-3

摘要

Abstract

关键词

Keywords

references